The Ultimate American Adventure
Cruise historic waterways and awe-inspiring coastlines
- You May Qualify for One or More American Cruise Lines Offers
Our Featured Deal
-
7 Night Tennessee Rivers
American Splendor
Departing from: Chattanooga, TennesseePorts of Call:- Decatur, Alabama
- Florence, Alabama
- Savannah, Tennessee
- Paducah, Kentucky
- Clarksville, Tennessee
- Nashville, Tennessee
Sailing Dates:- August 2025
interior fromNot Availableoceanview from$4,295$614pernightbalcony from$4,915$702pernightsuite from$6,800$971pernightRiverview from $4,295($614pernight)4.1 rating out of 5 (4 reviews)
American Cruise Lines
-
7 Night Lower Mississippi River
American Splendor
Departing from: New Orleans, LouisianaPorts of Call:- Houmas House Plantation, Louisiana
- Baton Rouge, Louisiana
- St. Francisville, Louisiana
- Natchez, Mississippi
- Vicksburg, Mississippi
- River Cruising
- Memphis, Tennessee
Sailing Dates:- February 2025
- March 2025
- April 2025
- May 2025
- June 2025
- July 2025
- November 2025
- February 2026
- March 2026
- April 2026
- May 2026
- June 2026
interior fromNot Availableoceanview from$3,895$556pernightbalcony from$4,515$645pernightsuite from$6,400$914pernightWas $4,915 – Save up to 8%Riverview from $3,895($556pernight)4.1 rating out of 5 (4 reviews) -
7 Night Music Cities
American Splendor
Departing from: Nashville, TennesseePorts of Call:- Clarksville, Tennessee
- Dover, Tennessee
- River Cruising
- Paducah, Kentucky
- River Cruising
- Memphis, Tennessee
Sailing Dates:- June 2025
- July 2025
- September 2025
- October 2025
interior fromNot Availableoceanview from$3,795$542pernightbalcony from$4,415$631pernightsuite from$6,300$900pernightWas $4,915 – Save up to 10%Riverview from $3,795($542pernight)4.1 rating out of 5 (4 reviews) -
7 Night The Tennessee Rivers
American Splendor
Departing from: Chattanooga, TennesseePorts of Call:- Decatur, Alabama
- Florence, Alabama
- Savannah, Tennessee
- Paducah, Kentucky
- River Cruising
- Nashville, Tennessee
Sailing Dates:- August 2026
- September 2026
interior fromNot Availableoceanview from$4,295$614pernightbalcony from$4,915$702pernightsuite from$6,800$971pernightRiverview from $4,295($614pernight)4.1 rating out of 5 (4 reviews) -
7 Night Chesapeake Bay
American Independence
Departing from: Baltimore, MarylandPorts of Call:- Yorktown, Virginia
- Crisfield, Maryland
- Cambridge, Maryland
- St. Michaels, Maryland
- Annapolis, Maryland
Sailing Dates:- May 2025
- May 2026
interior fromNot Availableoceanview from$4,610$659pernightbalcony from$5,490$784pernightsuite from$7,295$1,042pernightRiverview from $4,610($659pernight)4.6 rating out of 5 (8 reviews) -
7 Night Puget Sound & San Juan Islands
American Constellation
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Cruise San Juan Islands
- Victoria, British Columbia
- Port Townsend, Washington
- Poulsbo, Washington
Sailing Dates:- April 2025
- May 2025
- September 2025
- October 2025
interior fromNot Availableoceanview from$4,700$671pernightbalcony from$5,465$781pernightsuite from$7,295$1,042pernightWas $5,865 – Save up to 7%Riverview from $4,700($671pernight)4.9 rating out of 5 (7 reviews) -
7 Night Puget Sound & San Juan Islands
American Constitution
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Victoria, British Columbia
- Port Townsend, Washington
- Poulsbo, Washington
Sailing Dates:- April 2025
- May 2025
- September 2025
- October 2025
- March 2026
- April 2026
- May 2026
- September 2026
- October 2026
interior fromNot Availableoceanview from$4,600$657pernightbalcony from$5,365$766pernightsuite from$7,295$1,042pernightWas $5,865 – Save up to 9%Riverview from $4,600($657pernight)5 rating out of 5 (4 reviews) -
7 Night Lower Mississippi River
American Symphony
Departing from: New Orleans, LouisianaPorts of Call:- Houmas House Plantation, Louisiana
- Baton Rouge, Louisiana
- St. Francisville, Louisiana
- Natchez, Mississippi
- Vicksburg, Mississippi
- River Cruising
- Memphis, Tennessee
Sailing Dates:- December 2024
- July 2025
- September 2025
- April 2026
- July 2026
- September 2026
- November 2026
- December 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$4,415$631pernightsuite from$6,300$900pernightWas $4,915 – Save up to 10%Balcony from $4,415($631pernight)4.2 rating out of 5 (4 reviews) -
7 Night Lower Mississippi River
American Symphony
Departing from: Memphis, TennesseePorts of Call:- River Cruising
- Vicksburg, Mississippi
- Natchez, Mississippi
- St. Francisville, Louisiana
- Baton Rouge, Louisiana
- Houmas House Plantation, Louisiana
- New Orleans, Louisiana
Sailing Dates:- December 2024
- July 2025
- August 2025
- November 2025
- April 2026
- July 2026
- August 2026
- November 2026
- December 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$4,415$631pernightsuite from$6,300$900pernightWas $4,915 – Save up to 10%Balcony from $4,415($631pernight)4.2 rating out of 5 (4 reviews) -
7 Night Columbia & Snake Rivers
American Pride
Departing from: Portland, OregonPorts of Call:- Hayden Island, Portland, Oregon
- Astoria, Oregon
- Mount St. Helens, Washington
- Cruise Columbia River, Pacific Northwest, Usa
- The Dalles, Oregon
- Pendleton, Oregon
- Cruise Snake River, Pacific Northwest, Usa
- Clarkston, Washington
Sailing Dates:- April 2025
- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
- October 2025
interior fromNot Availableoceanview from$4,840$691pernightbalcony from$5,595$799pernightsuite from$7,795$1,114pernightWas $5,995 – Save up to 7%Riverview from $4,840($691pernight)4.4 rating out of 5 (7 reviews) -
7 Night Lower Mississippi River
American Melody
Departing from: Memphis, TennesseePorts of Call:- River Cruising
- Vicksburg, Mississippi
- Natchez, Mississippi
- St. Francisville, Louisiana
- Baton Rouge, Louisiana
- Houmas House Plantation, Louisiana
- New Orleans, Louisiana
Sailing Dates:- April 2025
- May 2025
- April 2026
- May 2026
- November 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$5,275$754pernightsuite from$7,295$1,042pernightBalcony from $5,275($754pernight)5 rating out of 5 (8 reviews) -
7 Night Upper Mississippi River
American Serenade
Departing from: St. Paul, MinnesotaPorts of Call:- Red Wing (Minneapolis), Minnesota
- Winona, Minnesota
- Dubuque, Iowa
- Davenport, Iowa
- Fort Madison, Iowa
- Hannibal, Missouri
- St. Louis, Missouri
Sailing Dates:- July 2025
- August 2025
- July 2026
- August 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$5,135$734pernightsuite from$7,295$1,042pernightWas $5,635 – Save up to 9%Balcony from $5,135($734pernight) -
7 Night Columbia & Snake Rivers
American Harmony
Departing from: Portland, OregonPorts of Call:- Hayden Island, Portland, Oregon
- Astoria, Oregon
- Mount St. Helens, Washington
- Cruise Columbia River, Pacific Northwest, Usa
- The Dalles, Oregon
- Pendleton, Oregon
- Cruise Snake River, Pacific Northwest, Usa
- Clarkston, Washington
Sailing Dates:- April 2025
- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
- October 2025
- March 2026
- April 2026
- May 2026
- June 2026
- July 2026
- August 2026
- September 2026
- October 2026
interior fromNot Availableoceanview fromNot Availablebalcony from$5,495$785pernightsuite from$7,790$1,113pernightWas $5,995 – Save up to 8%Balcony from $5,495($785pernight)5 rating out of 5 (6 reviews) -
7 Night Southeast Alaska
American Constellation
Departing from: Juneau, AlaskaPorts of Call:- Haines, Alaska
- Glacier Bay National Park, Alaska (Scenic Cruising)
- Petersburg, Alaska
- Cruise Wrangell Narrows, Alaska
- Wrangell, Alaska
- Cruise Tracy Arm Fjord, Alaska
Sailing Dates:- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
- May 2026
- June 2026
- July 2026
- August 2026
- September 2026
interior fromNot Availableoceanview from$5,900$843pernightbalcony from$6,865$981pernightsuite from$9,280$1,326pernightWas $7,365 – Save up to 7%Riverview from $5,900($843pernight)4.9 rating out of 5 (7 reviews) -
10 Night Alaskan Explorer
American Constellation
Departing from: Juneau, AlaskaPorts of Call:- Haines, Alaska
- Cruise Inside Passage, Alaska
- Glacier Bay National Park, Alaska (Scenic Cruising)
- Sitka, Alaska
- Wrangell, Alaska
- Cruise Wrangell Narrows, Alaska
- Petersburg, Alaska
- Cruise Inside Passage, Alaska
- Cruise Tracy Arm Fjord, Alaska
Sailing Dates:- June 2025
- July 2025
- August 2025
- June 2026
- July 2026
- August 2026
interior fromNot Availableoceanview from$8,525$853pernightbalcony from$9,915$992pernightsuite from$13,350$1,335pernightWas $10,665 – Save up to 7%Riverview from $8,525($853pernight)4.9 rating out of 5 (7 reviews) -
14 Night Alaska Inside Passage
American Constellation
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Cruise Queen Charlotte Sound, British Columbia
- Cruise Inside Passage, Alaska
- Ketchikan, Alaska
- Wrangell, Alaska
- Petersburg, Alaska
- Cruise Tracy Arm Fjord, Alaska
- Cruise Glacier Bay National Park
- Haines, Alaska
- Skagway, Alaska
- Juneau, Alaska
Sailing Dates:- May 2025
- May 2026
interior fromNot Availableoceanview from$9,810$701pernightbalcony from$11,435$817pernightsuite from$15,380$1,099pernightWas $12,435 – Save up to 8%Riverview from $9,810($701pernight)4.9 rating out of 5 (7 reviews)
American Cruise Line River Cruises
Request a Consultation
Our Personal Cruise Concierges can help you find the perfect luxury cruise with the best savings and extras, including an exclusive bonus just for booking with Cruises.com. Plus, we'll take care of all your travel needs - flight and hotel bookings, onboard reservations, and beyond - so all you have to do is pack.
Simply complete the form and a concierge will contact you shortly.
1-888-999-32711-888-999-3271 9AM to 8PM Monday through Friday, 9AM to 6PM Saturday through Sunday eastern standard time